San Francisco pressed its advantage in the preseason finale with a 30-23 win over Los Angeles at Levi’s Stadium, fueled by six total turnovers. Curtis Robinson capped the decisive late stand with a 32-yard pick-six, boosting his case for a 53-man roster spot as San Francisco trimmed depth further. The night also featured Uiagalelei’s two touchdowns for the Chargers but an ill-timed late turnover, Moody’s XP miss, muffed punts, and back-and-forth scoring that kept the outcome in doubt late.

Four takeaways turned into 27 points for the 49ers, while the Chargers repeatedly capitalized on miscues—muffs by Luke Grimm, plus a pair of early drives aided by recovered fumbles. Oronde Gadsden II found the end zone for Los Angeles, and Terique Owens’ preseason catch extended the Chargers’ drive. The result leaves SF at 2-1 in the preseason and LAC at 2-2, with any final roster decisions looming as the August 26 cutdown approaches.

The San Francisco 49ers have placed star wide receiver Brandon Aiyuk along with five others on the Active/Physically Unable to Perform (PUP) list ahead of the 2025 training camp. Aiyuk, who is recovering from major knee injuries sustained during last season's Week 7 matchup against the Kansas City Chiefs, will miss the start of training camp and could potentially miss the beginning of the upcoming season. Joining him on the PUP list are offensive tackle Andre Dillard, defensive lineman Yetur Gross-Matos, safety Malik Mustapha, wide receiver Ricky Pearsall, and linebacker Curtis Robinson.

This decision leaves the 49ers with a significant gap in their roster, particularly at wide receiver, as Aiyuk has been a crucial part of their offensive strategy. His recovery will be closely monitored as the team prepares for the season. The absence of such key players during training camp could impact the team's development and strength going into the regular season.